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The purpose of this proof‐of‐concept study was to develop three‐dimensional patient‐specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imaging...
Neuroprostheses based on electrical stimulation are becoming a therapeutic reality, dramatically improving the life of disabled people. They are based on neural interfaces that are designed to create an intimate contact with neural cells. These devices speak the language of electron currents, while the human nervous system uses ionic currents to communicate. A deep understanding of the complex interplay...
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressive disorder, and yet the mechanisms of its therapeutic effects remain largely unknown. A novel computational model is presented in this study to simulate and investigate direct cortical excitation caused by bitemporal electroconvulsive therapy (BT ECT), using a finite element model (FEM) of the human head. The skull...
Driven by the need for a more anatomically realistic ventricular model and with access to greater computational power the Auckland porcine ventricular model has been re-engineered based on the original anatomical recordings. The model retains an accurate representation of the ventricular geometry including the apex and valve rings and also the underlying tissue microstructure. A computational modeling...
Driven by the need for a more anatomically realistic ventricular model and with access to greater computational power the Auckland porcine ventricular model has been re-engineered based on the original anatomical recordings. The model retains an accurate representation of the ventricular geometry including the apex and valve rings and also the underlying tissue microstructure. A computational modeling...
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